1.
Crit Care
; 22(1): 215, 2018 Sep 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30231909
RESUMO
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such patients are often poorly represented in large clinical trials. Consequently, good evidence for effective treatment strategies is lacking. In this article, we describe a pragmatic, multi-faceted approach to managing patients with refractory septic shock based on our experience of toxin-mediated sepsis in a specialist referral centre. Many components of this strategy are inexpensive and widely accessible, and so may offer an opportunity to improve outcomes in these critically ill patients.
Assuntos
Choque Séptico/classificação , Choque Séptico/tratamento farmacológico , Corticosteroides/farmacologia , Corticosteroides/uso terapêutico , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Cardiotônicos/farmacologia , Cardiotônicos/uso terapêutico , Oxigenação por Membrana Extracorpórea/métodos , Humanos , Imunoglobulinas/farmacologia , Imunoglobulinas/uso terapêutico , Insuficiência de Múltiplos Órgãos/prevenção & controle , Terapia de Substituição Renal/métodos , Albumina Sérica Humana/farmacologia , Albumina Sérica Humana/uso terapêutico , Simendana/farmacologia , Simendana/uso terapêutico , Resultado do Tratamento , Vasoconstritores/farmacologia , Vasoconstritores/uso terapêutico
2.
Liver Transpl
; 22(12): 1727-1733, 2016 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27600579